Treatment

Women
are in a "Catch-22" position when it comes to drug treatments for
androgenetic alopecia. While many drugs may work to some degree for some
women, doctors are reluctant to prescribe them, and drug companies
aren't exactly falling over themselves to test existing or new drugs
specifically for their ability to prevent and treat female pattern
baldness.
Physicians are reluctant to use systemic treatment (a pill or other
form of internal treatment that affects your entire system) unless they
know that the hair loss is due to an excess of androgen in the system or
a sensitized "over-response" to the so-called "normal" amounts of
androgen in the system. That's because these systemic treatments may
lower the body's androgen levels. Therefore, physicians often choose
topical treatments (those that are applied directly to the scalp).
The best results from treatment happen when you begin treatment as
soon as possible after the hair loss begins because prolonged
androgenetic alopecia may destroy many of the hair follicles. The use of
anti-androgens after prolonged hair loss will at least help prevent
further hair loss and encourage some hair regrowth from those follicles
that have been dormant but are still viable, Stopping treatment will
result in the hair loss resuming if the androgens aren't kept in check
in some other way. Maintaining your vitamin and mineral levels helps
while you're on anti-androgen medications.
As always, treatments
have the best chance of being effective if they are geared to the cause
of the hair loss as well as to triggering hair growth.
Currently there is only one FDA approved treatment for female pattern hair loss.
Below you will find a list of treatments currently being used to
treat hair loss in women. Some of these drugs have not been approved by
the FDA for this particular application, however they have all been
approved for other applications and are used “off label” to treat hair
loss.
The effectiveness of these agents and methods vary from person to
person, but many women have found that using these treatments have made a
positive difference in their hair and their self-esteem.
Minoxidil 2% Topical Treatment
Minoxidil was first used in tablet form as a medicine to treat high
blood pressure (an antihypertensive). It was noticed that patients being
treated with minoxidil experienced excessive hair growth
(hypertrichosis) as a side effect. Further research showed that applying
a solution of minoxidil directly to the scalp could also stimulate hair
growth. The amount of minoxidil absorbed through the skin into the
bloodstream is usually too small to cause internal side effects.
Women with diffuse androgenetic alopecia can use minoxidil and it
actually seems to be more effective for women compared to men. The
makers of minoxidil recommend women only use the 2% concentration of
minoxidil and not 5%. The makers of minoxidil have not received FDA
approval for promoting 5% minoxidil or minoxidil extra strength for use
by women. Many dermatologists do prescribe minoxidil 5% for women with
androgenetic alopecia if used under their supervision. Some small
clinical trials have been conducted on 5% minoxidil for androgenetic
alopecia in women showing that indeed the 5% solution is significantly
more effective in both retaining and regrowing hair than the 2 %
solution.
In clinical studies of mostly white women aged 18-45 years with mild
to moderate degrees of hair loss, the following response to minoxidil
was reported: 19% of women reported moderate hair growth after using
minoxidil for 8 months (19% had moderate regrowth; 40% had minimal
regrowth). This compares with 7% of women reporting moderate hair
regrowth after using the placebo, the liquid without the active
ingredient in it, for 8 months (7% had moderate regrowth, 33% had
minimal regrowth).
The American Hair Loss Association recognizes the limitations of
topical minoxidil treatment in the fight against female androgenic
alopecia (female pattern baldness) therefore we recommend that you seek
out the advice of an informed hair loss specialist that can provide you
with information on the potential treatments listed on this website.
Androgen Receptor Inhibitors.
Aldactone / Spironolactone
Spironolactone or the more popular brand name Aldactone is in a class
of drugs called potassium-sparing diuretics (water pill). It is used to
reduce the amount of fluid in your body without causing the loss of
potassium. It is also used to treat hypertension (high blood pressure)
and edema (swelling) and used to treat potassium deficiency and
hyperaldosteronism (a hormonal disorder).
Spironolactone is an antiandrogen that works in two ways. Primarily
it slows down the production of androgens in the adrenal glands and
ovaries. Secondly it blocks the action of androgens in part by
preventing dihydrotestosterone from binding to its androgenetic
receptor.
Tagamet / Cimetidine
Cimetidine sold under the brand name Tagamet, belongs to a class of
histamine blockers used mainly to treat gastrointestinal ulcers. The
histamine blocking action prevents the stomach from producing excess
acid, allowing the body to heal the ulcer. Cimetidine also has a fairly
powerful anti-androgenic effect and has shown to block
dehydrotestosterone form binding the follicle receptor sites.
Cimetidine has been used to treat hirsuitism in women (excess facial
hair growth) and has been studied in women with androgenic alopecia
showing promising results. Because of the high doses needed to achieve
it’s hair raising results, men should not take cimettidine to treat
their hair loss due to possible feminizing effects including adverse
sexual side effects.
Cyproterone Acetate
Cyproterone Acetate is
used to reduce sex drive in men which have excessive sex drive and for
the treatment of pronounced sexual aggression. It is also prescribed to
treat severe hirsuitism in woman of childbearing age and also
androgenetic alopecia in women. Cyproterone acetate exerts its effects
by blocking the binding of DHT dihydrotestosterone to its receptors.
Cyproterone acetate is not available in the US and is thought of as
one of the last resorts for treating female pattern hair loss because of
its possible toxicity and long term side effects.
As with any drug side effects other than those listed may occur,
contact your doctor if you are experiencing a side effect that is
unusual or particularly bothersome
Estrogen/Progesterone
Also
known as hormone replacement therapy (HRT) and commonly prescribed at
menopause, estrogen and progesterone pills and creams are probably the
most common systemic form of treatment for androgenetic alopecia for
women in menopause or whose estrogen and/or progesterone are lacking for
other reasons.
Oral Contraceptives
Since birth control pills decrease the production of ovarian
androgens, they can be used to treat women's androgenetic alopecia. Keep
in mind, however, that the same cautions must be followed whether a
woman takes contraceptive pills solely to prevent contraception or to
treat female pattern baldness. For example, smokers over thirty-five who
take "the pill" are at higher risk for blood clots and other serious
conditions. Discuss your medical and lifestyle history thoroughly with
your doctor. Contraceptive pills come in various hormonal formulations,
and your doctor can determine which is right for your specific needs,
switching pills if necessary until you are physically and emotionally
comfortable with the formulation. Note:
Only low androgen
index
birth control pills should be used to treat hair loss. High androgen
index birth control pills actually contribute to hair loss by triggering
it or
enabling it once
it's been triggered by something else.
Nizoral/Ketoconazole
Available
as a topical treatment by prescription, Ketoconazole is currently used
as an antifungal agent in the treatment of fungal infections. It also
has anti-androgenic effects and can cause a reduction in the production
of testosterone and other androgens by the adrenal gland and by the male
and female reproductive organs (in women, the ovaries). Because of this
action, it can be used to help treat hair loss. Nizoral shampoo
contains 2 percent Ketoconazole and is prescribed not only for the
treatment of scalp conditions, but also in combination with other
treatments for androgenetic alopecia. A 1 percent version is now
available over-the-counter, but it may not be as effective as the 2
percent prescription strength. There are no significant side effects.
Propecia/ProscarThe
drug finasteride inhibits the enzyme 5-alpha reductase, thereby
inhibiting the production of prostate-harming, follicle killing DHT. It
was first marketed to treat the prostate under the brand name Proscar in
5 mg pills. In 1998, a 1 mg version with the brand name Propecia
entered the market as the first pill approved by the FDA for men's hair
loss. It works quite well for most men in both preventing hair loss and
triggering regrowth, and it may work for some women, although women must
not take it if they are pregnant and must not get pregnant while on the
drug because of the risk of birth defects in a male fetus. Less than 2
percent of men experience transient sexual side effects including
erectile and libido difficulties. In women these side effects do not
occur.
Cyproterone Acetate with Ethinyloestradiol
Sold under the brand name Diane 35 and Diane 50, this contraceptive
tablet is prescribed in Europe for women's androgenetic alopecia. The
drug works by blocking some of the actions of male hormones commonly
present in women. Although it's possible for the drug to stop further
hair loss and trigger regrowth of hair within about a year, it needs to
be used on an ongoing basis in order to maintain regrowth and eliminate
hair loss. Possible side effects include breast tenderness, headaches,
and decreased libido. It does have one good side effect- it helps
prevent osteoporosis. The drug is a combination of cyproterone and
estradiol, an estrogen. Both Diane 35 and Diane 50 contain 2 mg of
cyproterone. Diane 35 contains 0.035 mg of estradiol. Diane 50 contains
0.050 mg of estradiol. The drug is as effective as, if not more than,
spironolactone. Currently this drug is not available in the US.
Reviewed by Paul J. McAndrews, MD